Signature of immune-related metabolic genes predicts the prognosis of hepatocellular carcinoma.

ABSTRACT:

Introduction

The majority of liver cancer cases (90%) are attributed to hepatocellular carcinoma (HCC), which exhibits significant heterogeneity and an unfavorable prognosis. Modulating the immune response and metabolic processes play a crucial role in both the prevention and treatment of HCC. However, there is still a lack of comprehensive understanding regarding the immune-related metabolic genes that can accurately reflect the prognosis of HCC.

Methods

In order to address this issue, we developed a prognostic prediction model based on immune and metabolic genes. To evaluate the accuracy of our model, we performed survival analyses including Kaplan-Meier (K-M) curve and time-dependent receiver operating characteristic (ROC) curve. Furthermore, we compared the predictive pe

SUBMITTER: Zhuo W 

PROVIDER: S-EPMC11625796 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature