Perinuclear compartment controls calcineurin/MEF2 signaling for axonal outgrowth of hippocampal neurons.

ABSTRACT: Central to the process of axon elongation is the concept of compartmentalized signaling, which involves the A-kinase anchoring protein (AKAP)-dependent organization of signaling pathways within distinct subcellular domains. This spatial organization is also critical for translating electrical activity into biochemical events. Despite intensive research, the detailed mechanisms by which the spatial separation of signaling pathways governs axonal outgrowth and pathfinding remain unresolved. In this study, we demonstrate that mAKAPα (AKAP6), located in the perinuclear space of primary hippocampal neurons, scaffolds calcineurin, NFAT, and MEF2 transcription factors for activity-dependent axon elongation. By employing anchoring disruptors, we show that the mAKAPα/calcineurin/MEF2 signaling path

SUBMITTER: Mackiewicz J 

PROVIDER: S-EPMC11625814 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature