Altered metabolic profiles of dermatomyositis with different myositis-specific autoantibodies associated with clinical phenotype.

ABSTRACT:

Introduction

Dermatomyositis (DM) is an idiopathic inflammatory myopathy. Because of clinical heterogeneity, the metabolite profile of DM patients with different myositis-specific autoantibodies (MSAs) remains elusive. This study aimed to explore the metabolomics characteristics of the serum in DM with different MSAs, low or high disease activity, and interstitial lung disease.

Methods

Untargeted metabolomics profiling was performed in the serum of a discovery cohort (n=96) and a validation cohort (n=40), consisting of DM patients with MSAs, low or high disease activity, and/or interstitial lung disease (DM-ILD) compared to age- and gender-matched healthy controls (HCs).

Results

The lipid profile in DM was found to be abnormal, especially dysregulated glycerophospholi

SUBMITTER: Wang N 

PROVIDER: S-EPMC11625817 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature