Autoimmune screening panel in patients with multiple sclerosis: A Vienna multiple sclerosis database study.

ABSTRACT:

Background and purpose

Autoimmune screening panels (ASPs) are often ordered as a part of the diagnostic workup in people with suspected multiple sclerosis (MS). However, data on the significance of ASP seropositivity in MS are scarce. This study aimed to investigate whether routine implementation of ASPs is viable in MS diagnostic workup.

Methods

In this retrospective study, we included patients from the Vienna Multiple Sclerosis Database who were diagnosed with MS according to current McDonald criteria between 2014 and 2021 and had an ASP performed.

Results

We analyzed 212 patients (mean age at serology = 30.4 [SD = 8.5] years, 67% female). Red flag symptoms for presence of systemic autoimmune disease were reported by 5.6% of patients during initial evaluation (sicca

SUBMITTER: Fottinger F 

PROVIDER: S-EPMC11625921 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature