Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs.

ABSTRACT: The identification of causal relationships between specific genes and social, behavioral, and health outcomes is challenging due to environmental confounding from population stratification and dynastic genetic effects. Existing methods to eliminate environmental confounding leverage random genetic variation resulting from recombination and require within-family dyadic genetic data (i.e., parent-child and/or sibling pairs), meaning they can only be applied in relatively small and selected samples. We introduce the phenotype differences model and provide derivations showing that it-under plausible assumptions-provides consistent (and, in certain cases, unbiased) estimates of genetic effects using just a single individual's genotype. Then, leveraging distinct samples of fully and parti

SUBMITTER: Trejo S 

PROVIDER: S-EPMC11626128 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature