Caenorhabditis elegans inositol hexaphosphate pathways couple to RNA interference and pathogen defense.

ABSTRACT: RNA interference (RNAi) is an evolutionarily conserved pathway that defends against viral infections in diverse organisms. Caenorhabditis elegans mutations that enhance RNAi have revealed pathways that may regulate antiviral defense. A genetic screen for C. elegans mutations that fail to up-regulate a defense response reporter transgene detected mutations that enhance RNAi to silence this reporter gene in the inositol polyphosphate multikinase impk-1, the synMuv B gene lin-15B, and the pathogen defense response gene pals-22. Using other assays for enhanced RNAi, we found that the impk-1 alleles and an ippk-1 gene inactivation of a later step in inositol hexaphosphate (IP₆) synthesis, and the lin-15B and pals-22 allel

SUBMITTER: Xu W 

PROVIDER: S-EPMC11626161 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature