Allergen-specific sublingual immunotherapy altered gut microbiota in patients with allergic rhinitis.

ABSTRACT:

Introduction

Allergen-specific immunotherapy (AIT) induces long-term immune tolerance to allergens and is effective for treating allergic rhinitis (AR). However, the impact of sublingual immunotherapy (SLIT) on gut microbiota from AR patients and its correlation with treatment efficacy remains unclear.

Methods

In the present study, we enrolled 24 AR patients sensitized to Dermatophagoides farinae (Der-f) and 6 healthy donors (HD). All AR patients received SLIT treatment using standardized Der-f drops. Stool samples were collected from AR patients before treatment, and 1- and 3-months post-treatment, as well as from HD, for metagenomic sequencing analysis.

Results

AR patients had significantly lower richness and diversity in gut microbiota compared to HD, with notable

SUBMITTER: Wu J 

PROVIDER: S-EPMC11626388 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature