Multi-target macrocycles: pyrogallol derivatives to control multiple pathological factors associated with Alzheimer's disease.

ABSTRACT: Designing multi-target chemical tools is a vital approach to understanding the pathology of Alzheimer's disease (AD), which involves a complex network of pathological factors, such as free organic radicals, amyloid-β (Aβ), and metal-bound Aβ (metal-Aβ). The pyrogallol moiety, known for its ability to lower redox potentials and interact with both Aβ and metal ions, presents a promising framework for this molecular design. Here we show how simple structural variations of pyrogallol can be used to enhance its ability to scavenge free organic radicals and regulate the aggregation of both metal-free Aβ and metal-Aβ. By incorporating multiple pyrogllol units into a macrocyclic scaffold via methylene bridges, we achieve synergistic reactivity against several pathological targets. Our struc

SUBMITTER: Kwak J 

PROVIDER: S-EPMC11626466 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature