Solvent-Directed Social Chiral Self-Sorting in Pd₂L₄ Coordination Cages.

ABSTRACT: A family of Pd₂L₄ cages prepared from ligands based on an axially chiral diamino-[1,1'-biazulene] motif (serving as a unique azulene-based surrogate of the ubiquitous BINOL moiety) is reported. We show that preparing a cage starting from the racemate of a shorter bis-monodentate ligand derivative, equipped with pyridine donor groups, leads to integrative ("social") chiral self-sorting, exclusively yielding the meso-trans product, but only in a selection of solvents. This phenomenon is driven by individual solvent molecules acting as hydrogen bonding tethers between the amino groups of neighboring ligands, thereby locking the final coordination cage in a single isomeric form. The experimental (solvent-dependent NMR, single-crystal X-ray diffraction) obser

SUBMITTER: Walther A 

PROVIDER: S-EPMC11626499 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature