MRI markers of idiopathic normal pressure hydrocephalus in a population study with 791 participants: Exploring reference values and associations.

ABSTRACT: PurposeEpidemiological studies on idiopathic normal pressure hydrocephalus (iNPH) imaging markers and their normal values are scarce. This population-based study aimed to analyze several morphologic and volumetric iNPH-related imaging markers in a large sample, determining their distribution, diagnostic accuracy, suggested cut-offs, and associations with iNPH symptoms.MethodsThis cross-sectional study included 791 70 year olds, 40 with radiologically probable iNPH (iNPH_Radiol) and 751 without iNPH features (reference). MRI measures included Evans index (EI), z-EI, brain per ventricle ratio at anterior (BVR_AC) and posterior commissures (BVR_PC), sulcal compression, Sylvian fissure enlargement, callosal angle, diameter of temporal horns, 3^rd and 4

SUBMITTER: Constantinescu C 

PROVIDER: S-EPMC11626555 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature