Clinicopathological and molecular features of claudin-18 isoform 2 expression in patients with colorectal cancer: a single-center retrospective study.

ABSTRACT:

Background

Claudin-18 isoform 2 (CLDN18.2) is expressed in multiple cancers and is a promising target for antitumor therapy. However, there is limited knowledge regarding the prevalence and characteristics of CLDN18.2-positive colorectal cancer (CRC).

Objectives

To determine the clinicopathological and molecular features of patients with CLDN18.2-positive CRC.

Design

Single-center retrospective study.

Methods

A total of 805 patients who underwent surgical resection for pathological stage I-III CRC at the National Cancer Center Hospital (Tokyo, Japan) between 1997 and 2019 were identified. Expression of CLDN18.2 was evaluated by immunohistochemistry. The association of CLDN18.2 expression with clinicopathological features and treatment outcomes was assess

SUBMITTER: Takamizawa S 

PROVIDER: S-EPMC11626668 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature