Musculoskeletal ultrasound characteristics of checkpoint inhibitor-associated inflammatory arthritis.

ABSTRACT:

Background

Cancer immunotherapy with checkpoint inhibition (ICI) has revolutionized the treatment of solid cancers; however, it is associated with a spectrum of immune-related adverse events (irAEs), including inflammatory arthritis. Here we report our experience with the use of point-of-care musculoskeletal ultrasound (MSKUS) and provide a description of MSKUS findings in patients with definite musculoskeletal irAEs.

Methods

Patients ≥18 years who received ICI at the Mass General Cancer Center from 2010-2019 were referred to rheumatology by oncology for evaluation of musculoskeletal symptoms following ICI therapy. Fifty-five patients with suspected MSK irAEs had MSKUS performed and interpreted by the same ultrasonographer. Findings were reviewed and confirmed by a blinded U

SUBMITTER: Nasrallah M 

PROVIDER: S-EPMC11626687 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature