Long-term cancer and overall mortality associated with drinking water nitrate in the United States.

ABSTRACT:

Objectives

Nitrate is a probable carcinogen regulated in drinking water by the US Environmental Protection Agency (EPA) to a maximum contaminant level (MCL) of 10 mg/L nitrate-nitrogen (NO₃-N; equivalent to 44.3 mg/L NO₃). We aimed to determine the association of US drinking water nitrate levels with overall as well as cardiovascular, cancer, and other cause mortality.

Study design

This study used a population-based retrospective cohort design.

Methods

We analyzed data from 2029 participants of the 2005-2006 National Health and Nutrition Examination Survey followed for mortality until 2019 for a median of 13.9 years. We used Cox proportional hazards regression to estimate the hazard ratio (HR) and 95% confidence interval (CI) for mortality associ

SUBMITTER: Mendy A 

PROVIDER: S-EPMC11626709 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature