SIX1 expression and its clinicopathological significance: difference between classic and follicular variant papillary thyroid carcinoma.

ABSTRACT:

Background

Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, representing the majority of thyroid cancer cases. Most patients with PTC have an excellent prognosis following treatment, yet approximately 10% face mortality within ten years, primarily due to lymph node metastasis (LNM) or local recurrence. The SIX1 gene, a member of the SIX gene superfamily, encodes a transcription factor integral to the development of certain tissues during embryogenesis. The impact of SIX1 in different subtypes of PTC has not been studied previously.

Objective

The purpose of this study was to investigate the expression of SIX1 protein in PTC and to explore its relationship with clinical behavior in two subtypes of PTC: classic PTC (C-PTC) and follicular variant P

SUBMITTER: Khalil EI 

PROVIDER: S-EPMC11626750 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature