Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin ortholog Tpm^Cdc8.

ABSTRACT: Cables formed by head-to-tail polymerization of tropomyosin, localized along the length of sarcomeric and cytoskeletal actin filaments, play a key role in regulating a wide range of motile and contractile processes. The stability of tropomyosin cables, their interaction with actin filaments and the functional properties of the resulting co-filaments are thought to be affected by N-terminal acetylation of tropomyosin. Here, we present high-resolution structures of cables formed by acetylated and unacetylated Schizosaccharomyces pombe tropomyosin ortholog Tpm^Cdc8. The crystal structures represent different types of cables, each consisting of Tpm^Cdc8 homodimers in a different conformation. The structures show how the interactions of the residues in the overlap junction c

SUBMITTER: Reinke PYA 

PROVIDER: S-EPMC11626781 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature