Versican binds collagen via its G3 domain and regulates the organization and mechanics of collagenous matrices.

ABSTRACT: Type I collagen is the most abundant structural protein in the body and, with other fibrillar collagens, forms the fibrous network of the extracellular matrix. Another group of extracellular matrix polymers, the glycosaminoglycans, and glycosaminoglycan-modified proteoglycans, play important roles in regulating collagen behaviors and contribute to the compositional, structural, and mechanical complexity of the extracellular matrix. While the binding between collagen and small leucine-rich proteoglycans has been studied in detail, the interactions between collagen and the large bottlebrush proteoglycan versican are not well understood. Here, we report that versican binds collagen directly and regulates collagen structure and mechanics. Versican colocalizes with collagen fibers in vivo and b

SUBMITTER: Chen D 

PROVIDER: S-EPMC11626796 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature