Exploring the effects of culture conditions on Yapsin (YPS) gene expression in Nakaseomyces glabratus.

ABSTRACT: Nakaseomyces glabratus, previously known as Candida glabrata, has the great potential to cause systemic fungal infections despite its similarity to baker's yeast. Its pathogenicity is attributed to the production of numerous virulence factors, among which the YPS genes (YPS1-YPS11) encoding aspartyl proteases have yet to be sufficiently characterized, and limited studies suggest their involvement in cellular homeostasis. The study's novelty is an investigation of the role of YPS in N. glabratus's ability to adapt to different host environments. For this purpose, we isolated RNA from N. glabratus cells grown in both host niche-mimicking culture media, such as artificial saliva (AS) and vagina-simulating media (VS), as well as standard

SUBMITTER: Bednarek A 

PROVIDER: S-EPMC11627043 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature