H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication.

ABSTRACT: During infection, avian influenza virus (AIV) triggers endoplasmic reticulum (ER) stress, a well-established phenomenon in previous research. The Golgi apparatus, situated downstream of the ER and crucial for protein trafficking, may be impacted by AIV infection. However, it remains unclear whether this induces Golgi apparatus stress (GAS) and its implications for AIV replication. We investigated the morphological changes in the Golgi apparatus and identified GAS response pathways following infection with the H5 subtype AIV strain A/Mallard/Huadong/S/2005. The results showed that AIV infection induced significant swelling and fragmentation of the Golgi apparatus in A549 cells, indicating the presence of GAS. Among the analyzed GAS response pathways, TFE3 was significantly activated during

SUBMITTER: Yin Y 

PROVIDER: S-EPMC11627363 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature