Screening of potential regulatory genes in carotid atherosclerosis vascular immune microenvironment.

ABSTRACT:

Background

Immune microenvironment is one of the essential characteristics of carotid atherosclerosis (CAS), which cannot be reversed by drug therapy alone. Thus, there is a pressing need to develop novel immunoregulatory strategies to delay this pathological process that drives cardiovascular-related diseases. This study aimed to detect changes in the immune microenvironment of vascular tissues at various stages of carotid atherosclerosis, as well as cluster and stratify vascular tissue samples based on the infiltration levels of immune cell subtypes to distinguish immune phenotypes and identify potential hub genes regulating the immune microenvironment of carotid atherosclerosis.

Materials and methods

RNA sequencing datasets for CAS vascular tissue and healthy vascular tis

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11627393 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature