Differential protein expression and metabolite profiling in glaucoma: Insights from a multi-omics analysis.

ABSTRACT: Various substances within the aqueous humor (AH) can directly or indirectly impact intraocular tissues associated with intraocular pressure (IOP), a critical factor in glaucoma development. This study aims to investigate individual changes in these AH substances and the interactions among altered components through a multi-omics approach. LC/MS analysis was conducted on AH samples from patients with exfoliation syndrome (XFS, n = 5), exfoliation glaucoma (XFG, n = 4), primary open-angle glaucoma (POAG, n = 11), and cataracts (control group, n = 7). Subsequently, differentially expressed proteins and metabolites among groups, alterations in their network interactions, and their biological functions were examined. Both data-independent acquisition and data-dependent acquisition methods were

SUBMITTER: Mok JH 

PROVIDER: S-EPMC11627470 | biostudies-literature | 2024 Nov-Dec

REPOSITORIES: biostudies-literature