Cross-species alignment along the chronological axis reveals evolutionary effect on structural development of the human brain.

ABSTRACT: Disentangling the evolution mysteries of the human brain has always been an imperative endeavor in neuroscience. Although many previous comparative studies revealed genetic, brain structural and connectivity distinctness between human and other nonhuman primates, the brain evolutional mechanism is still largely unclear. Here, we proposed to embed the brain anatomy of human and macaque in the developmental chronological axis to construct cross-species predictive model to quantitatively characterize brain evolution using two large public human and macaque datasets. We observed that applying the trained models within-species could well predict the chronological age. Interestingly, we found the model trained in macaque showed a higher accuracy in predicting the chronological age of human than

SUBMITTER: Li Y 

PROVIDER: S-EPMC11627501 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature