Salivary peptidomic profiling of chronic gingivostomatitis in cats by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry and nanoscale liquid chromatography-tandem mass spectrometry.

ABSTRACT:

Background

Chronic gingivostomatitis in cats (FCGS) is a moderately to severely painful condition, potentially caused by inadequate immune response to oral antigenic stimulation. Salivary peptidome analysis can identify inflammatory protein mediators and pathways involved in oral mucosal immune activation and may indicate potential therapeutic options for FCGS.

Objective

Evaluate the diversity and abundance of salivary peptides in cats with FCGS using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and nanoscale liquid chromatography-tandem mass spectrometry (nano LC-MS/MS).

Animals

Thirty-two cats with FCGS and 18 healthy controls.

Methods

Case-control cross-sectional study. We compared the salivary peptide profiles

SUBMITTER: Ploypetch S 

PROVIDER: S-EPMC11627522 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature