Unified bursting strategies in ectopic and endogenous even-skipped expression patterns.

ABSTRACT: Transcription often occurs in bursts as gene promoters switch stochastically between active and inactive states. Enhancers can dictate transcriptional activity in animal development through the modulation of burst frequency, duration, or amplitude. Previous studies observed that different enhancers can achieve a wide range of transcriptional outputs through the same strategies of bursting control. For example, in Berrocal et al., 2020, we showed that despite responding to different transcription factors, all even-skipped enhancers increase transcription by upregulating burst frequency and amplitude while burst duration remains largely constant. These shared bursting strategies suggest that a unified molecular mechanism constraints how enhancers modulate transcriptional output. Alter

SUBMITTER: Berrocal A 

PROVIDER: S-EPMC11627552 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature