Uptake of H-ferritin by Glioblastoma stem cells and its impact on their invasion capacity.

ABSTRACT:

Purpose

Iron acquisition is key to maintaining cell survival and function. Cancer cells in general are considered to have an insatiable iron need. Iron delivery via the transferrin/transferrin receptor pathway has been the canonical iron uptake mechanism. Recently, however, our laboratory and others have explored the ability of ferritin, particularly the H-subunit, to deliver iron to a variety of cell types. Here, we investigate whether Glioblastoma (GBM) initiating cells (GICs), a small population of stem-like cells, are known for their iron addiction and invasive nature acquire exogenous ferritin, as a source of iron. We further assess the functional impact of ferritin uptake on the invasion capacity of the GICs.

Methods

To establish that H-ferritin can bind to human GBM,

SUBMITTER: Pandya Shesh B 

PROVIDER: S-EPMC11628165 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature