In vivo rat brain mapping of multiple gray matter water populations using nonparametric D(ω)-R₁-R₂ distributions MRI.

ABSTRACT: Massively multidimensional diffusion magnetic resonance imaging combines tensor-valued encoding, oscillating gradients, and diffusion-relaxation correlation to provide multicomponent subvoxel parameters depicting some tissue microstructural features. This method was successfully implemented ex vivo in microimaging systems and clinical conditions with tensor-valued gradient waveform of variable duration giving access to a narrow diffusion frequency (ω) range. We demonstrate here its preclinical in vivo implementation with a protocol of 389 contrast images probing a wide diffusion frequency range of 18 to 92 Hz at b-values up to 2.1 ms/μm² enabled by the use of modulated gradient waveforms and combined with multislice high-resolution and low-distortion echo planar imaging acquisit

SUBMITTER: Yon M 

PROVIDER: S-EPMC11628177 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature