Tau Accumulation Induces Microglial State Alterations in Alzheimer's Disease Model Mice.

ABSTRACT: Unique microglial states have been identified in Alzheimer's disease (AD) model mice and postmortem AD brains. Although it has been well documented that amyloid-β accumulation induces the alteration of microglial states, the relationship between tau pathology and microglial states remains incompletely understood because of a lack of suitable AD models. In the present study, we generated a novel AD model mouse by the intracerebral administration of tau purified from human brains with primary age-related tauopathy into App knock-in mice with humanized tau. Immunohistochemical analyses revealed that Dectin-1-positive disease-associated microglia were increased in the AD model mice after tau accumulation in the brain. We then performed single-nucleus RNA sequencing on the AD model mice

SUBMITTER: Nagata K 

PROVIDER: S-EPMC11628182 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature