Long non-coding RNA H19 as a prognostic biomarker for oral squamous cell carcinoma.

ABSTRACT:

Background

H19, a 2.3 kb lncRNA, has been linked to tumor metastasis and progression, but its significance in oral squamous cell carcinoma (OSCC) remains unclear. H19 was initially thought to have a tumor-suppressive function, but recent studies have shown that it possesses both tumor-promoting and suppressive functions. The variation in H19 expression may be due to the influence of tobacco or low basal expression levels. However, there are limited studies available on the association between H19 and its role in the prognosis of OSCC.

Objective

The present study analyzes the expression of H19 correlated with clinicopathological parameters, tobacco habit, loco-regional recurrence, and overall survival.

Methods

A longitudinal study was undertaken using 96 formalin-fixed

SUBMITTER: Kumar K 

PROVIDER: S-EPMC11628285 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature