Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through <i>lncRNA57RIK</i>.

ABSTRACT: Lipopolysaccharide (LPS) mediated caspases-4 (humans) and caspase-11 (rodent) (caspase-4/11) signaling can cause maturation of inflammatory cytokine IL-1β and cellular pyroptosis in the macrophages through guanylate-binding proteins (GBPs). However, how caspase-4/11s bind with GBPs together to activate caspase-4/11 by LPS remains elusive. We here found that BA derivatives from gut microbiota can regulate sensitivity of macrophages to LPS and Gram-negative bacteria through lncRNA57RIK. BA derivatives such as deoxycholic acid (DCA) could induce lncRNA57RIK expression through sphingosine-1-phosphate receptor 2 (S1PR2) in the macrophages of mice and humans. Both murine and human lncRNA57RIK knockout (KO) macrophages did not produce immune response(s) to LPS or gram negativ

SUBMITTER: Gao Y 

PROVIDER: S-EPMC11628326 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature