Myeloid-Derived Suppressor Cells Induce Exhaustion-Like CD8⁺ T Cells during JEV Infection.

ABSTRACT: Japanese encephalitis (JE), caused by Japanese encephalitis virus (JEV), is a mosquito-borne zoonotic disease and a leading cause of viral encephalitis worldwide. While JEV has the ability to traverse the blood-brain barrier (BBB), the precise mechanisms by which it inhibits the immune response prior to penetrating the BBB remain unclear, presenting obstacles in the development of efficacious therapeutic interventions. This study investigated the impact of JEV on CD8⁺ T cell responses, with a particular focus on the dysfunction of CD8⁺ T cells during JEV infection. Our results demonstrated that JEV infection significantly elevated the expression of PD-1 and TIM-3 on CD8⁺ T cells, which are markers of T cell exhaustion, leading to inhibited function and impa

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11628328 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature