Complement C1q is a key player in tumor-associated macrophage-mediated CD8⁺ T cell and NK cell dysfunction in malignant pleural effusion.

ABSTRACT: Macrophages play a crucial role in malignant pleural effusion (MPE), a frequent complication of advanced cancer. While C1q⁺ macrophages have been identified as a pro-tumoral cluster, direct evidence supporting the role of C1q-mediated macrophages remains to be elucidated. This study employed global and macrophage-specific knockout mice to investigate the role of C1q in MPE. The data demonstrated that C1q deficiency in macrophages suppressed MPE and prolonged mouse survival. scRNA-seq analysis of the C1qa^-/- mouse MPE model revealed that C1q deficiency significantly decreased the proportion of M2 macrophages in MPE. In vitro experiments suggested that C1q expression was gradually upregulated during M2 polarization, which was C1q-dependent, as was antigen present

SUBMITTER: Yi FS 

PROVIDER: S-EPMC11628339 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature