Development of Advanced Oral-on-a-Chip: Replicating the Intricate Human Oral Microenvironment.

ABSTRACT: The interactions between various cellular populations in the oral cavity, including gingival keratinocytes, tonsil-resident stem cells, periodontal ligament fibroblasts, and vascular endothelial cells, are crucial for maintaining oral health. These interactions regulate essential functions like tooth support and pathogen defense. However, conventional 2D and 3D in vitro models often fail to capture the complexity of these interactions and the multicellular architecture of the oral environment. To address this limitation, we developed an advanced 3D oral-on-a-chip system that mimics the dynamic microenvironment of oral tissues. This system incorporates multiple oral cells into a 3D structure made from natural polymers such as collagen and hyaluronic acid, crosslinked by blood-coagula

SUBMITTER: Kim SR 

PROVIDER: S-EPMC11628345 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature