Optimal thresholds and key parameters for predicting influenza A virus transmission events in ferrets.

ABSTRACT: Although assessments of influenza A virus transmissibility in the ferret model play a critical role in pandemic risk evaluations, few studies have investigated which virological data collected from virus-inoculated animals are most predictive of subsequent virus transmission to naïve contacts. We compiled viral titer data from >475 ferrets inoculated with 97 contemporary IAV (including high- and low-pathogenicity avian, swine-origin, and human viruses of multiple HA subtypes) that served as donors for assessments of virus transmission in the presence of direct contact (DCT) or via respiratory droplets (RDT). A diversity of molecular determinants, clinical parameters, and infectious titer measurements and derived quantities were examined to identify which metrics were most statistically sup

SUBMITTER: Kieran TJ 

PROVIDER: S-EPMC11628394 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature