Breast cancer metastasis progression is associated with elevated activity of kynurenine monooxygenase and kynureninase.

ABSTRACT:

Introduction

Metastasis remains the major cause of death in breast cancer (BrCa) and lacks specific treatment strategies. The kynurenine pathway (KP) has been suggested as a key mechanism facilitating progression of BrCa. While KP activity has been explored in primary BrCa, its role in metastasis remains unclear. To better understand this, we examined changes in the KP of BrCa with no metastasis compared to BCa that produced local or distant metastases. Given that the cancer cell secretome plays a role in metastasis, we also investigated the relationship between changes in KP activity and serum proteins of patients with local or distant metastases.

Methods

To investigate changes in the KP in BrCa, with and without metastasis, we quantified KP metabolites in blood sera collec

SUBMITTER: Girithar HN 

PROVIDER: S-EPMC11628561 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature