Temporal dynamics of immune cell patterns in bladder cancer patients receiving Bacillus Calmette-Guerin therapy.

ABSTRACT:

Background

Bacillus Calmette-Guérin (BCG) is capable of enhancing the infiltration of immune cells into the tumour. However the temporal dynamics of immune cell patterns in patients receiving BCG instillation remains unclear.

Methods

Ninety-six patients who underwent intravesical BCG therapy, comprising 46 responders and 50 non-responders, were retrospectively enroled to explore the evolving immune landscape. This study involved a detailed examination of sequential samples collected before, during, and after BCG treatment to assess BCG's influence on the immune microenvironment, employing techniques such as immunohistochemistry, fluorescent multiplex immunohistochemistry, and mass spectrometry techniques.

Results

Our study found that initial BCG instillation leads to

SUBMITTER: Lu JL 

PROVIDER: S-EPMC11628562 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature