Macrophages enhance sodium channel expression in cardiomyocytes.

ABSTRACT: Cardiac macrophages facilitate electrical conduction through the atrioventricular-node (AV) in mice. A possible role for cardiomyocyte-macrophage coupling on the effect of antiarrhythmic therapy has not been investigated yet. Holter monitoring was conducted in LysM^CrexCsf1r^LsL-DTR mice (MM^DTR) under baseline conditions and after an elctrophysiological stress test by flecainide. In vivo effects were recapitulated in vitro by patch-clamp experiments. The underlying mechanism was characterized by expression and localization analysis of connexin43 (Cx43) and voltage-gated-sodium-channel-5 (Na_v1.5). ECG monitoring in MM^DTR mice did not show any significant conduction abnormalities but a significantly attenuated flecainide-induced extension

SUBMITTER: Bogert NV 

PROVIDER: S-EPMC11628573 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature