Phenotypical differences of neutrophils patrolling tumour-draining lymph nodes in head and neck cancer.

ABSTRACT:

Background

The complexity and heterogeneity of neutrophils are recognized, especially their roles in modulating inflammation and cancer immune responses. The detailed functions of neutrophils in human tumour-draining lymph nodes (TDLNs), specifically in the context of head and neck cancer, remain inadequately characterized.

Aim

This study aims to delineate the phenotypic diversity of neutrophils in TDLNs, non-tumour-draining lymph nodes (nTDLNs) from patients with oral squamous cell carcinoma (OSCC), and to evaluate their correlation with clinical outcomes.

Methods

A flow cytometry-based investigation.

Results

Neutrophils manifest a tissue-specific heterogeneity with significant phenotypic differences between compartments. A substantial fraction of neutrophils

SUBMITTER: Ekstedt S 

PROVIDER: S-EPMC11628601 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature