Lung damage in SARS-CoV-2 patients: An autopsy study in the era of vaccination.

ABSTRACT:

Aims

The contribution of SARS-CoV-2 infection on lung damage and the effect of vaccination on either containing the number of deaths or mitigating lung damage has not been systematically investigated.

Methods

Post-mortem analysis was performed among consecutive in-patients with COVID-19 deceased in the Province of Trieste (2020-2022). The outcomes of the study were (i) rates of in-hospital mortality, (ii) contribution of COVID-19 to death, (iii) histological extent of lung injury and (iv) impact of vaccination.

Results

A total of 1038 consecutive hospitalized patients who died with SARS-CoV-2 infection were autopsied and deep histological analysis of the lungs was performed in a randomly selected sample of 508 cases. Among them, SARS-CoV-2 infection was (a) the cause

SUBMITTER: Bussani R 

PROVIDER: S-EPMC11628649 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature