Forward-in-time simulation of chromosomal rearrangements: The invisible backbone that sustains long-term adaptation.

ABSTRACT: While chromosomal rearrangements are ubiquitous in all domains of life, very little is known about their evolutionary significance, mostly because, apart from a few specifically studied and well-documented mechanisms (interaction with recombination, gene duplication, etc.), very few models take them into account. As a consequence, we lack a general theory to account for their direct and indirect contributions to evolution. Here, we propose Aevol, a forward-in-time simulation platform specifically dedicated to unravelling the evolutionary significance of chromosomal rearrangements (CR) compared to local mutations (LM). Using the platform, we evolve populations of organisms in four conditions characterized by an increasing diversity of mutational operators-from substitutions alone to a mix o

SUBMITTER: Banse P 

PROVIDER: S-EPMC11628651 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature