The impact of dynamic caudal type homeobox 2 expression on the differentiation of human trophoblast lineage during implantation.

ABSTRACT: The trophoblast lineage differentiation represents a rate-limiting step in successful embryo implantation. Adhesion, invasion and migration processes within the trophoblast are governed by several transcription factors. Among them, CDX2 is a critical regulator shaping the destiny of the trophoblast. While its altered expression is a linchpin initiating embryo implantation in mice, the precise influence of CDX2 on the functionality and lineage differentiation of early human trophoblast remains unclear. In this study, we employed well-established human trophoblast stem cell (hTSC) lines with CDX2 overexpression coupled with a 3D in vitro culture system for early human embryos. We revealed that the downregulation of CDX2 is a prerequisite for syncytialization during human embryo implantation

SUBMITTER: Rong L 

PROVIDER: S-EPMC11628739 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature