Exemplifying interspecies variation of liposome <i>in vivo</i> fate by the effects of anti-PEG antibodies.

ABSTRACT: The different fate of liposomes among species has been discovered and mentioned in many studies, but the underlying mechanisms have not been explored. In the present work, we concentrated on the in vivo fate of PEGylated liposomes (sLip) in three commonly used species (mice, rats, and dogs). It was exhibited that the accelerated blood clearance (ABC) phenomenon and hypersensitivity in large animals (beagle dogs) were much more significant than that in rodents. We demonstrated that anti-PEG IgM (partially) and complement (mostly) determined the elimination of sLip and linked the distinct interspecies performances with the diverse complement capacity among species. Based on the data from animals and clinical patients, it was revealed that the fate of sLip in large animals was closer t

SUBMITTER: Wu E 

PROVIDER: S-EPMC11628802 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature