Morphology and intervesicle distances in condensates of synaptic vesicles and synapsin.

ABSTRACT: Synaptic vesicle clusters or pools are functionally important constituents of chemical synapses. In the so-called reserve and the active pools, neurotransmitter-loaded synaptic vesicles (SVs) are stored and conditioned for fusion with the synaptic membrane and subsequent neurotransmitter release during synaptic activity. Vesicle clusters can be considered as so-called membraneless compartments, which form by liquid-liquid phase separation. Synapsin as one of the most abundant synaptic proteins has been identified as a major driver of pool formation. It has been shown to induce liquid-liquid phase separation and form condensates on its own in solution, but also has been shown to integrate vesicles into condensates in vitro. In this process, the intrinsically disordered region of synapsin is

SUBMITTER: Neuhaus C 

PROVIDER: S-EPMC11628805 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature