GPR17 modulates anxiety-like behaviors <i>via</i> basolateral amygdala to ventral hippocampal CA1 glutamatergic projection.

ABSTRACT: Anxiety disorders are one of the most epidemic and chronic psychiatric disorders. An incomplete understanding of anxiety pathophysiology has limited the development of highly effective drugs against these disorders. GPR17 has been shown to be involved in multiple sclerosis and some acute brain injury disorders. However, no study has investigated the role of GPR17 in psychiatric disorders. In a well-established chronic restraint stress (CRS) mouse model, using a combination of pharmacological and molecular biology techniques, viral tracing, in vitro electrophysiology recordings, in vivo fiber photometry, chemogenetic manipulations and behavioral tests, we demonstrated that CRS induced anxiety-like behaviors and increased the expression of GPR17 in basolateral amygdala (BLA) gl

SUBMITTER: Nie R 

PROVIDER: S-EPMC11628806 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature