Integration of kinetic data into affinity-based models for improved T cell specificity prediction.

ABSTRACT: T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) interactions that result in T cell activation are complex and have been distinguished by their equilibrium affinity and kinetic profiles. While prior affinity-based models can successfully predict meaningful TCR-pMHC interactions in many cases, they occasionally fail at identifying TCR-pMHC interactions with low binding affinity. This study analyzes TCR-pMHC systems for which empirical kinetic and affinity data exist and prior affinity-based predictions have failed. We identify criteria for TCR-pMHC systems with available kinetic information where the introduction of a correction factor improves energy-based model predictions. This kinetic correction factor offers a means to refine existing models with additional dat

SUBMITTER: Ghoreyshi ZS 

PROVIDER: S-EPMC11628827 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature