PPAR<i>α</i> affects hepatic lipid homeostasis by perturbing necroptosis signals in the intestinal epithelium.

ABSTRACT: Rapid turnover of the intestinal epithelium is a critical strategy to balance the uptake of nutrients and defend against environmental insults, whereas inappropriate death promotes the spread of inflammation. PPARα is highly expressed in the small intestine and regulates the absorption of dietary lipids. However, as a key mediator of inflammation, the impact of intestinal PPARα signaling on cell death pathways is unknown. Here, we show that Pparα deficiency of intestinal epithelium up-regulates necroptosis signals, disrupts the gut vascular barrier, and promotes LPS translocation into the liver. Intestinal Pparα deficiency drives age-related hepatic steatosis and aggravates hepatic fibrosis induced by a high-fat plus high-sucrose diet (HFHS). PPARα levels

SUBMITTER: Na S 

PROVIDER: S-EPMC11628832 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature