Dynamic processes of fate decision in inducible bistable systems.

ABSTRACT: The process of biological fate decision regulated by gene regulatory networks involves numerous complex dynamical interactions among many components. Mathematical modeling typically employed ordinary differential equations and steady-state analysis, which has yielded valuable quantitative insights. However, stable states predicted by theoretical models often fail to capture transient or metastable phenomena that occur during most observation periods in experimental or real biological systems. We attribute this discrepancy to the omission of dynamic processes of various complex interactions. Here, we demonstrate the influence of delays in gene regulatory steps and the timescales of the external induction on the dynamic processes of the fate decision in inducible bistable systems. We propose

SUBMITTER: Chen S 

PROVIDER: S-EPMC11628857 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature