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High-dose IV ascorbic acid therapy for patients with CCUS with TET2 mutations.

ABSTRACT:

Abstract

This phase 2 trial assessed high-dose IV ascorbic acid in TET2 mutant clonal cytopenia. Eight of 10 patients were eligible for response assessment, with no responses at week 20 by International Working Group Myelodysplasia Syndromes/Neoplasms criteria. This trial was registered at www.clinicaltrials.gov as #NCT03418038.

SUBMITTER: Xie Z

PROVIDER: S-EPMC11628862 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature

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High-dose IV ascorbic acid therapy for patients with CCUS with TET2 mutations.

Xie Zhuoer Z Fernandez Jenna J Lasho Terra T Finke Christy C Amundson Michelle M McCullough Kristen B KB LaPlant Betsy R BR Mangaonkar Abhishek A AA Gangat Naseema N Reichard Kaaren K KK Elliott Michelle M Witzig Thomas E TE Patnaik Mrinal M MM

Blood 20241201 23

<h4>Abstract</h4>This phase 2 trial assessed high-dose IV ascorbic acid in TET2 mutant clonal cytopenia. Eight of 10 patients were eligible for response assessment, with no responses at week 20 by International Working Group Myelodysplasia Syndromes/Neoplasms criteria. This trial was registered at www.clinicaltrials.gov as #NCT03418038. ...[more]

PMID: 39352751

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