Rise of a CD27^- IgD^- CD11c⁺ B cells population in kidney recipients achieving long-term graft stability under immunosuppression.

ABSTRACT: The use of immunosuppressive treatment is required to prevent rejection events, even a long time after kidney transplantation despite rare recipients achieving long-term graft stability without the need for immunosuppressive treatment, called operationally tolerant patients (TOLs). We comprehensively investigate the immune system of long-term IS recipients (LTTs) and TOLs to highlight their shared and unique immune features. Blood immune cell phenotyping was performed by spectral cytometry. Samples from 34 individuals were analyzed, including 6 LTTs, 8 TOLs, 10 stable patients at 1 year posttransplantation (STAs), and 10 healthy volunteers. B cells differed between LTTs and TOLs with a decreased total B-cell frequency and the acquisition of a memory phenotype in LTTs whereas a naive phenot

SUBMITTER: Brinas F 

PROVIDER: S-EPMC11628921 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature