An Overview of Monkeypox Virus Detection in Different Clinical Samples and Analysis of Temporal Viral Load Dynamics.

ABSTRACT: Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV), and since May 2022, tens of thousands of cases have been reported in non-endemic countries. We aimed to evaluate the suitability of different sample types for mpox diagnostic and assess the temporal dynamics of viral load. We evaluated 1914 samples from 953 laboratory-confirmed cases. The positivity rate was higher for lesion (91.3%) and rectal swabs (86.1%) when compared with oropharyngeal swabs (69.5%) and urines (41.2%), indicating higher viral loads for the former. Supporting this, lesion and rectal swabs showed lower median PCR C_t values (C_t = 23 and C_t = 24), compared to oropharyngeal swabs and urines (C_t = 31). Stable MPXV loads were observed in swabs from lesions up to 30 da

SUBMITTER: Cordeiro R 

PROVIDER: S-EPMC11628931 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature