Cost-effectiveness of long-acting progestogens versus the combined oral contraceptives pill for preventing recurrence of endometriosis-related pain following surgery: an economic evaluation alongside the PRE-EMPT trial.

ABSTRACT:

Objectives

To evaluate the cost-effectiveness of long-acting progestogens (LAP), including levonorgestrel-releasing intrauterine system (LNG-IUS) and depot-medroxyprogesterone acetate (DMPA), compared with the combined oral contraceptives pill (COCP) in preventing recurrence of endometriosis-related pain postsurgery.

Design

Within-trial economic evaluation alongside a multicentre, pragmatic, parallel-group, open-label, randomised controlled trial (Preventing Recurrence of Endometriosis by means of Long-Acting Progestogen Therapy trial).

Setting

Thirty-four UK hospitals recruiting participants from November 2015 to March 2019.

Patients

Four hundred and five women aged 16-45 years undergoing conservative endometriosis surgery.

Interventions

The ratio of 1:

SUBMITTER: Melyda M 

PROVIDER: S-EPMC11628948 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature