Acute hepatitis of unknown aetiology in children: evidence for and against causal relationships with SARS-CoV-2, HAdv and AAV2.

ABSTRACT:

Background

The cause of acute paediatric hepatitis of unknown aetiology (2022) has not been established despite extensive investigation.

Objective

To summarise the evidence for and against a causal role for human adenovirus (HAdv), adeno-associated virus 2 (AAV-2) and SARS-CoV-2 in outbreaks of paediatric hepatitis in 2022.

Methods

We appraised and summarised relevant evidence for each of the Bradford Hill criteria for causality using quantitative (statistical modelling) and qualitative (narrative coherence) approaches. Each team member scored the evidence base for each criterion separately for HAdv, AAV-2 and SARS-CoV-2; differences were resolved by discussion. We additionally examined criteria of strength and temporality by examining the lagged association between S

SUBMITTER: Gurdasani D 

PROVIDER: S-EPMC11628968 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature